Dinoprostone (Prostaglandin E2)
Dosages;
Combinations; See below
Dinoprostone (Prostaglandin E2) Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Glandin-E | Nabiqasim Industries (Pvt) Ltd | Globe Pharmacy Ltd., | 3mg | 4 | Pessaries | KES 3,480 | |
| Propess | Ferring Pharmaceuticals | MacNaughton Limited | 10mg | 5 | Pessaries | KES 59,762.80 | |
| Prostin E | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 3mg | 4 | Pessaries | KES 3,899.35 | |
| Glandin-E2 | Nabiqakaum Pharma | Harley's Limited | 3mg | 4 | Pessaries | KES 3,721.00 | |
| ProstinE2 | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 3mg | 4 | Pessaries | KES 4,709.00 |
| Dinoprostone (Prostaglandin E2) More info | |
|---|---|
| Mode Of Action | Stimulation of gravid uterus to produce myometrial contractions e.g. carboprast |
| Drug Indication | Induction of labour; elective abortion (between 12-18 wks of gestation); treatment of incomplete abortion; therapeutic abortion (e.g. in cases of intra-uterine fetal death and congenital abnormalities incompatible with life); cervical ripening; treatment of postpartum haemorrhage; treatment of benign hydatidiform mole |
| Precautions | Pregnancy termination can fail; history of anaemia; hypertension or hypotension; cardiovascular disease; diabetes mellitus; renal disease; pre-eclampsia; uterine fibroids; cervical stenosis; uterine surgery; epilepsy; glaucoma; multiparity. |
| Contra-Indications | Allergic reaction to dinoprostone or related drugs; history of asthma; active pulmonary disease; significant cephalopelvic disproportion; malpresentation of fetus; active pelvic inflammatory disease; ruptured membranes. |
| Side Effects | Anaphylaxis; bronchoconstriction; burning eyes; endometritis; second-degree heart block; urinary retention; bradycardia; adynamic ileus; peripheral vasoconstriction; tachycardia; and increased uterine bleeding or pain; severe and continuing abdominal or stomach pain; double vision; dysuria; hematuria; paresthesias; leg, back, chest, or shoulder pain. |
| Dosage | Vaginally. Insert high into posterior fornix 3mg followed by another 3mg 6-8hrs later incase the labour is not established (max. 6mg) |